Elafin and cancer

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August undefined, 2024

WebJul 30, 2024 · Another study showed that estrogen receptor-positive breast cancer tumors have lower elafin mRNA expression than estrogen receptor-negative counterparts 42. Estrogen, via estrogen receptor ... WebNovel therapeutic targets are urgently needed to improve ovarian cancer treatment efficacy. Elafin, also known as skin-derived antileukoprotease (SKALP) or peptidase inhibitor 3 …

International Journal of Cancer - Wiley Online Library

WebWe measured their serum elafin levels at baseline and followed them until the date of cancer death or until January 2024, the end of this study. Those with high serum elafin levels … WebMar 26, 2024 · Elafin dramatically enhanced the metastasis of HCC cells both in vitro and in vivo by interacting with EGFR and activating EGFR/AKT signalling. Moreover, Elafin … nuclear medicine technologist schools

Frontiers Elafin is related to immune infiltration and …

WebNov 10, 2024 · Elafin may protect against human neutrophil elastase-mediated cleavage of receptors such as CD40, CD80, and CD86 on dendritic cells, which are essential for the … WebJan 27, 2014 · Elafin increases cellular proliferation in ovarian cancer To further characterize the biological relationship between Elafin expression and poor survival, we analyzed a … WebOct 1, 2011 · Elafin-based therapy is currently being tested in clinical trials in the context of improving clinical outcomes in patients undergoing coronary artery bypass surgery, esophagectomy for esophageal... nine east 33rd printing

Therapeutic potential of human elafin - PubMed

Evaluation of Elafin as a Prognostic Biomarker in Acute Graft …

WebDec 1, 2006 · Abstract. B140 Ovarian cancer (OvCa) is a leading cause of cancer-related death of women in the United States and Europe. Three-quarters of patients have locally … WebApr 24, 2002 · In view of the fact that both elafin and SLPI are expressed in multiple epithelium including that in the reproductive tract and airways, we hypothesized that HE4 may also be expressed in cells of ... nineears headphonesWebNov 5, 2024 · Background: A major cause of mortality in patients receiving hematopoietic stem cell transplantation (HCT) is acute graft-versus-host disease (GVHD), a multiorgan disorder that includes the skin, liver and gastrointestinal tract.We have previously identified elafin, a protease inhibitor overexpressed in inflamed epidermis, as a diagnostic … nuclear medicine technology board

"WebJul 19, 2010 · Elafin expression is induced in prostate cancer cells treated with genistein, a protein tyrosine kinase blocker that inhibits cell growth and induces apoptosis, 11 and in … " - Elafin and cancer

Elafin and cancer

Proteins with whey-acidic-protein motifs and cancer

WebJun 4, 2012 · Imbalance between NE and its inhibitors is implicated in the pathogenesis of many chronic inflammatory diseases. We hypothesize that elafin is deregulated during breast cancer progression,... WebSep 14, 2010 · Elafin, an endogenous inhibitor of neutrophil elastase, is expressed in human mammary epithelial cells but is transcriptionally downregulated in breast cancer cells. We …

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WebDownload scientific diagram Elafin increases ovarian cancer cell proliferation. (a) Kaplan–Meier analysis for OS in OC patients according to the expression of PI3 probe 41469_at (n=1058). (b ... WebJan 2, 2024 · Thus, the detection of elafin is beneficial to diagnosis and treatment selection. 1. Introduction Ovarian cancer (OC) is known as one of the most lethal gynecologic malignancies, ranking as the fourth …

WebMay 1, 2007 · Abstract. 421 Cyclin E is a positive regulator of the G1 to S phase transition of the cell cycle. Previously, we have reported that cyclin E is overexpressed and present in low molecular weight (LMW) isoforms in breast tumor tissues compared to normal tissues. The frequent appearance of the LMW forms of cyclin E is a very strong predictor of poor … WebApr 15, 2024 · These multipotent cells can be isolated from diverse tissue sources like bone marrow (BM), adipose tissues (AT), umbilical cord (UC) etc. Current studies suggest that MSCs exert strong antimicrobial activity in direct or indirect way by secreting AMPs and other antimicrobial proteins (Alcayaga-Miranda et al. 2024 ).

WebFeb 1, 2006 · For example, the proangiogenic role of WFDC1 6 strongly suggests that this protein, like antileukoproteinase 1 and elafin, 3 also has a role in tissue remodelling and repair—processes that are commonly associated with the inflammatory response, cancer progression, and invasion by tumoral cells. 69 Tumour growth and wound healing are ... WebThe majority of breast cancer cell lines lack elafin expression compared to human mammary epithelial cells. In this study, we hypothesized that elafin is downregulated during breast and ovarian ...

WebPhase II trials are underway to investigate the therapeutic effects of elafin on post-operative inflammation and the clinical consequences of major surgery. Of particular interest is the …

WebApr 14, 2024 · Colonic elafin mRNA and protein expression were not associated with clinical disease activity and histological injury in IBD patients, but stricturing CD patients had lower colonic elafin expression than non-stricturing CD patients. ... The healthy subjects did not have concurrent cancer, infection, obesity (BMI>30), prediabetes, or diabetes. nuclear medicine technologist starting salaryWebSep 17, 2015 · A few studies have reported high elafin expressions in tumors to be correlated with poor prognosis of breast cancer [12,29], ovarian cancer [23] and … nine east 33rd street apartment baltimoreWebMay 1, 2008 · Abstract. 5395 Ovarian cancer (OvCa) affects over 25,000 women annually in the US, with a mortality rate greater than 70%. The poor survival is due in part to three quarter of all patients are diagnosed with advance stage disease. When ovarian cancer is diagnosed in its early stage the 5-year survival rate exceeds 90%. Early detection would … nine eight centralWebJan 15, 2013 · Altered expressions of SLPI and elafin have been identified in several carcinomas, and it appears that these aberrations may play a role in tumor formation, stimulation of metastatic potential,... nuclear medicine technology board reviewWebJun 9, 2024 · The relationship between Elafin expression and clinicopathological features was analyzed by immunostaining scores and mRNA data of colorectal cancer patients. … nine eastern to centralWebSep 8, 2014 · The loss of elafin expression during breast cancer progression may promote tumor growth as a consequence of increased NE activity. To address the role of NE in … nuclear medicine technology board certifiedWebElafin, also known as peptidase inhibitor 3 or skin-derived antileukoprotease ( SKALP ), is a protein that in humans is encoded by the PI3 gene. [3] [4] [5] Function [ edit] This gene … nuclear medicine technology jobs