Mechanisms of resistance to cisplatin

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August undefined, 2024

WebJul 1, 2007 · Cisplatin resistance has been studied to a greater extent than has carboplatin resistance. However, in reviewing platinum resistance mechanisms, the overall available data strongly suggest that resistance mechanisms are very similar for cisplatin and carboplatin (although not always identical). WebAug 1, 2001 · Knowledge of the mechanism of action of cisplatin has improved our understanding of resistance. Decreased intracellular concentration due to decreased drug uptake, increased reflux or...

New Insights into Mechanisms of Cisplatin Resistance: …

WebFeb 28, 2024 · However, the principal mechanisms by which 13 and, above all, 18 overcome cisplatin resistance rely on three different possible mechanisms: the inhibition of endogenous P-gp expression, a transporter that enables the active efflux of the drug from the cancer cells; the generation of ROS inside the cells that can reduce GSH levels, a … WebThe intracellular targets and mechanisms of action/resistance of oxaliplatin differ from that of its predecessors, cisplatin and carboplatin. It is important to note that oxaliplatin is more active in colon cells [ 6 ], and that cisplatin-resistant cell lines are sensitive to oxaliplatin [ 7, 8 ]. Intracellular targets and mechanisms of action heaney district and circle

Molecules Free Full-Text The Challenging Treatment of Cisplatin …

WebMar 17, 2016 · The majority of ovarian tumors eventually recur in a drug resistant form. Using cisplatin sensitive and resistant cell lines assembled into 3D spheroids we profiled gene expression and identified candidate mechanisms and biological pathways associated with cisplatin resistance. OVCAR-8 human ovarian carcinoma cells were exposed to sub … WebJul 1, 2007 · Resistance has also been associated with abnormal sorting of some lysosomal proteins and cisplatin transporters into an exosomal pathway [75], and with drug … WebJul 1, 2001 · Mechanisms of resistance to cisplatin. The use of cisplatin in cancer chemotherapy is limited by acquired or intrinsic resistance of cells to the drug. Cisplatin enters the cells and its chloride ligands are replaced by water, forming aquated species that react with nucleophilic sites in cellular macromolecules. heaney digging youtube

A structure-based mechanism of cisplatin resistance mediated by ... - PNAS

http://connectioncenter.3m.com/cisplatin+research+paper WebApplications of Machine Learning to Predict Cisplatin Resistance in Lung Cancer . Fulltext; Metrics; Get Permission; Cite this article; Authors Gao Y, Lyu Q, Luo P , Li M, Zhou R, Zhang … mountain bike price in philippinesWebJul 1, 2001 · Postulated mechanisms of resistance to cisplatin include the following: reduced intracellular accumulation of cisplatin which may arise because of decreased … heaney electrical

"WebJun 26, 2024 · It may be considered as one of the mechanisms of resistance to cisplatin-mediated cell death. Fig. 2: Signal transduction cascades mediating nonapoptotic forms of cell death induced by... " - Mechanisms of resistance to cisplatin

Mechanisms of resistance to cisplatin

Cisplatin 17. Drug Resistance - Chemistry LibreTexts

WebOct 22, 2024 · 2.2 Epigenetic Mechanisms and Cisplatin Resistance in OSCC The epigenetic modifications include several different forms such as methylation, histone modification, and regulation of non-coding RNAs. Genetic mechanisms and epigenetic mechanisms influence each other and work together to obtain the characteristics of cancer ( 26 ). WebFeb 28, 2024 · However, the principal mechanisms by which 13 and, above all, 18 overcome cisplatin resistance rely on three different possible mechanisms: the inhibition of …

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WebMar 28, 2024 · Objective: Cisplatin resistance development is a major obstacle in ovarian cancer treatment. One of the most important mechanisms underlying cisplatin resistance is drug detoxification by glutathione. WebMar 22, 2024 · EMT-associated chemotherapy resistance in SCC. To investigate the role and the mechanisms of resistance to therapy in EMT tumour cells in vivo, we used a genetically induced mouse model of skin SCCs combining the expression of oncogenic Kras (Kras G12D) with the deletion of Trp53 and the expression of a YFP reporter in hair follicle …

WebSep 24, 2024 · Cisplatin (CDDP) is the drug of choice against different types of cancer. However, tumor cells can acquire resistance to the damage caused by cisplatin, generating genetic and epigenetic changes that lead to the generation of resistance and the activation of intrinsic resistance mechanisms in cancer cells. Among them, we can find mutations, … WebVarious mechanisms of tumor resistance to DDP have been described, and, most recently, these mechanisms have been classified as follows: (1) pre-target resistance (before cisplatin binds to DNA), (2) target resistance (directly associated with DNA-cisplatin adducts), (3) post-target resistance (associated with apoptosis caused by DDP-mediated ...

WebJul 28, 2024 · Inside the tumor cell, decreased drug import, increased drug export, increased drug inactivation by detoxification enzymes, increased DNA damage repair, and inactivated cell death signaling are major mechanisms leading to cisplatin resistance.

WebJan 20, 2024 · Therefore, revealing the underlying mechanisms of chemotherapy resistance in LSCC and identifying novel biomarkers for targeted therapy are urgently required to improving the dismal outcome of this disease. ... Upregulation of FOXD2-AS1 enhanced cisplatin resistance of laryngeal cancer cells in vitro.

WebJun 20, 2024 · We propose here a new mechanism of cisplatin resistance mediated by glutathione transferase (GST) P1-1, as a cisplatin-binding protein. Our results show that … heaney dodgers pitcherWebJul 28, 2024 · Although cisplatin has been a pivotal chemotherapy drug in treating patients with various types of cancer for decades, drug resistance has been a major clinical … mountain bike price in the philippinesWebMechanisms of resistance to cisplatin Alan Eastman Chapter 115 Accesses 29 Citations Part of the Cancer Treatment and Research book series (CTAR,volume 57) Abstract … mountain bike price rangeWebMay 13, 2024 · Interestingly, cisplatin treatment of head and neck (UM-SCC-38) cancer cells resulted in similar heterogenous cell cycle and cell fate responses (Luong et al., 2016), implying that the non-genetic cell cycle-dependent mechanisms of resistance we observed here may translate to multiple cancer types beyond LUAD. heaney family treeWebAug 24, 2024 · Components of tumor microenvironment reported to affect cisplatin resistance. These components can contribute to cisplatin resistance through decreased … mountain bike prescott azWebIn this review, we will summarize our findings in ovarian cancer model systems as regards resistance mechanisms and describe related work of other investigators. In addition, less studied mechanistic possibilities will be noted and experience in reversal of drug resistance will be described. Keywords. Ovarian Cancer; Alkylating Agent mountain bike prices in the philippinesWebNov 15, 1987 · Differential expression of collateral sensitivity or resistance to cisplatin in human bladder carcinoma cell lines pre-exposed in vitro to either X-irradiation or cisplatin ... was significantly elevated at later times. These findings suggest that mechanisms associated with the expression of resistance and collateral sensitivity to cisplatin ... mountainbike profi tobi