WebbAbstract. Mitotic catastrophe (MC) has long been considered as a mode of cell death that results from premature or inappropriate entry of cells into mitosis and can be caused by chemical or physical stresses. Whereas it initially was depicted as the main form of cell death induced by ionizing radiation, it is today known to be triggered also by ... WebbMitotic catastrophe was proposed to be an onco-suppressive mechanism and the evasion of mitotic catastrophe constitutes one of the gateways to cancer development. Thus, stimulation of mitotic catastrophe appears to be a promising strategy in cancer treatment. Indeed, several chemotherapeutic drugs are currently used at concentrations that ...
Abnormal expression of H-Ras induces S-phase arrest and mitotic ...
WebbMitotic catastrophe (MC) is a mechanism of delayed mitotic-linked cell death resulting from aberrant mitosis, although there is an ongoing debate over whether MC is a … WebbMitotic catastrophe has been observed in response to treatment with a variety of genotoxic agents that have different mechanisms of action (Table 22.1).These data demonstrate that mitotic catastrophe is an important and widely observed mode of death in response to treatment with genotoxic agents [58].It is likely that these cells undergo … in-c3
Mitotic Catastrophe - an overview ScienceDirect Topics
WebbMitotic catastrophe is a common mode of tumor cell death. Cancer cells with a defective cell-cycle checkpoint often enter mitosis with damaged or under replicated chromosomes following genotoxic treatment. WebbVarför inträffar skred och ras? Förutom naturliga skäl och människans påverkan så kan skogsavverkning också leda till förändrad stabilitet i marken eftersom … Webb9 dec. 2024 · Although the phenomenon of mitotic catastrophe was first described more than 80 years ago, only recently has this term been used to explain a mechanism of cell death linked to delayed mitosis. Several mechanisms have been suggested for mitotic catastrophe development and cell fate. Depending on molecular perturbations, mitotic … in-c7