WebA cell-permeable and aqueous soluble (~ 1 mg/mL or 2.26 mM at pH 7.4) biphenylylpentanoic acid that selectively inhibits human, but not yeast, E2 Ub-conjugating enzyme Cdc34- dependent substrates ubiquitinations in p27 kip1-SCF Skp2, Sic1-SCF Cdc4 (IC 50 = 1.72 & 2.5 µM, respectively), Cyclin E-SCF Fbw7, IκBα-SCF βTrCP ubiquitination … WebApr 17, 2000 · molecular switch that changes p27Kip1 from an inhibitor to a substrate? Biochemical studies have begun to address how p27 may act as both inhibitor and …

CDKN1B cyclin dependent kinase inhibitor 1B [ (human)]

Web批注本地保存成功，开通会员云端永久保存 去开通 WebCyclin-dependent kinase inhibitor 1B (p27 Kip1) is an enzyme inhibitor that in humans is encoded by the CDKN1B gene. It encodes a protein which belongs to the Cip/Kip family of cyclin dependent kinase (Cdk) inhibitor … iran nuclear plants

Sic1 - an overview ScienceDirect Topics

WebSic1 and p27Kip1 inhibitors. In support to these evidences, Sic1 inhibits in vitro the Cdk2/cyclin A kinase activity. The goal of this study was to establish whether mammalian … Webp27 Kip1 is a member of the Cip/Kip family of cyclin-dependent kinase inhibitors. Like its relatives, p57 Kip2 and p21 Waf1/Cip1, the ability to enforce the G1 restriction point is … WebApr 23, 1999 · The yeast homolog of Rbx1 is a subunit and potent activator of the Cdc53-containing SCF Cdc4 ubiquitin ligase required for ubiquitination of the cyclin-dependent … iran oclock