The pleiotropic benefits of statins

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August undefined, 2024

Webb1 juni 2004 · These non-lipid-lowering (pleiotropic) effects of statin therapy are believed to include antiinflammatory actions, property to reverse endothelial dysfunction by decreasing LDL oxidation and increasing nitric oxide bioavailability. Webb10 mars 2015 · In summary, statins are probably both under- and over-utilized in older adults. For example, it is estimated that only 40-60% of patients over 65 are prescribed a statin after an acute MI; 24 conversely, a recent study found that 30% of patients with a cancer diagnosis were dispensed a statin within 30 days of dying. 25 For primary …

The Role of Statins in the Management of Heart Failure with …

Webb12 juni 2015 · This finding “suggests that reduction of LDL cholesterol levels per se explains the effect of statins on coronary heart disease,” rather than some pleiotropic benefit specific to statins, the editorialists wrote. “It’s nice to have all the different options for patients,” Cannon said. WebbCurrently, new benefits of statins, not dependent on the reduction of LDL cholesterol, have been proposed in the setting of ACS. These effects, which are not dependent on the reduction of LDL cholesterol, are called pleiotropic [Liao, 2005]. Some of the possible effects of statins, which may participate in the benefits that they represent for canon laser shot lbp 1420

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Webb1 aug. 2024 · Clinical benefits, such as reduction of recurrent ischemic events, have been documented in a recent prospective study after short-term treatment with statins. 134 Mechanistic explanations of the benefits are derived not only from the actions of statin on atherogenic lipoproteins (VLDL, IDL, and LDL) but equally on inflammation, endothelial … Webb17 okt. 2024 · However, the clinical benefit of statin-induced elevation of HDL-cholesterol is unclear from trial data, ... statins have pleiotropic benefits including prevention of LDL oxidation. View full-text. Webb6 jan. 2024 · The statins have been used for 30 years to prevent coronary artery disease and stroke. Their primary mechanism of action is the lowering of serum cholesterol through inhibiting hepatic cholesterol … flagship trailways ri

JCI - Isoprenoids as mediators of the biological effects of statins

Statins and the Eye: What You Might Not Know - Review of …

Webb15 juni 2007 · Furthermore, at normal doses, statins inhibit cholesterol metabolism by macrophages and may lead to a reduction in macrophage activation and participation in … Webb7 mars 2024 · The pleiotropic benefits of statins include the ability to reduce CD47 and amplify the effect of pro-efferocytic therapies in atherosclerosis Main. Atherosclerosis is a lipoprotein-driven, inflammatory process underlying heart attack and stroke and is … canon laser shot lbp 1210 driver downloadWebb1 maj 2024 · The so-called pleiotropic effects are mediated by the reduction of isoprenoids, such as farnesyl-pyrophosphate and geranylgeranyl-pyrophosphate, necessary for the activation of small GTPases like Rho and Ras proteins (Fig. 1A).Statins diversely inhibit RhoA and Rac1 prenylation, modulating endothelial nitric oxide (NO) synthase … flagship transport

"WebbDOI: 10.1016/S1734-1140(10)70247-4 Corpus ID: 4742496; Effects of statins on nitric oxide/cGMP signaling in human umbilical vein endothelial cells. @article{Meda2010EffectsOS, title={Effects of statins on nitric oxide/cGMP signaling in human umbilical vein endothelial cells.}, author={Claudia Meda and Christian Plank and … " - The pleiotropic benefits of statins

The pleiotropic benefits of statins

Focus on Statins: Lipid-Lowering Mechanisms and Beyond

Webb27 okt. 2016 · Individualized Statin Benefit for Determining Statin Eligibility in the Primary Prevention of Cardiovascular Disease. Circulation. 2016 Apr 19;133(16):1574-81. Robinson JG, Ray K. Moving Toward the Next Paradigm for Cardiovascular Prevention. Circulation. 2016 Apr 19;133(16):1533-6. Webb1 okt. 2014 · Recent experimental and clinical evidence indicates that some of the cholesterol-independent or "pleiotropic" effects of statins involve improving or restoring endothelial function, enhancing the stability of atherosclerotic plaques, and decreasing oxidative stress and vascular inflammation. 1,280 PDF

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Webb26 okt. 2024 · Statins are a class of drugs used to lower low-density lipoprotein cholesterol and are amongst the most prescribed medications worldwide. Most statins work as a … Webb6 maj 2016 · These may be predicted as harmful or beneficial effects of the drug. The most wonderful positive pleiotropic effects of statins are anti-inflammatory, anti-proliferative, antithrombotic, improving endothelial dysfunction, and neuroprotective besides many others (Lewington et al. 2007; DuBroff and De Lorgeril 2015 ).

WebbHowever, it is not clear that the purported effectiveness of statins in neurodegenerative disorders is directly related to cholesterol-lowering effects of these agents; rather, the pleiotropic functions of statins likely play critical roles. Moreover, it is becoming more apparent with… Visualizza altro WebbRajagopal et al. / Cumhuriyet Dental Journal, 25(2): 200-205, 2024 201 Table 1. History of Statins YEAR INVENTION 1784 François Poulletier, a French doctor-chemist obtained real cholesterol from ...

Webb20 maj 2024 · One of the factors to be considered when evaluating outcomes of lipid-lowering treatment with statins is their solubility. Therefore, the role of both hydrophilic … WebbDespite the progressions in COVID-19 understanding, the optimization of patient-specific therapies remains a challenge. Statins, the most widely prescribed lipid-lowering drugs, …

WebbSaeid Ghavami Associate Editor at Elsevier, Frontiers, PLOS, and MDPI publishing group

Webbwith cardiac history. How might the increasing use of statins, with pleiotropic effects, including antiinflammatory activity, alter the effects of immunization? With universal recommendations for influenza vaccination for persons > 6 months of age, how will herd or community immunity affect population levels of influenza activity? canon lasers imageclass mf6180dw cartridgeWebb13 feb. 2024 · Indeed, several randomized controlled trials showed the benefits of statins both in the primary and secondary prevention of cardiovascular disease, which appear to be primarily due to LDL cholesterol (LDL-C) reduction but also to antiinflammatory, antithrombotic, antioxidant, and plaque-stabilizing effects [5,6,7,8,9,10,11,12]. flagship travel marbleheadWebb20 nov. 2024 · While not increasing the risk of bleeding, these pleiotropic antithrombotic effects may contribute to the overall cardiovascular benefits of statins and certain antihypertensive, antiarrhythmic and antidiabetic drugs. Clinicians and scientists may thus want to consider the ancillary effects in their daily practice and research. flagship transport llcWebbThe noncausal theory supports the premise that clinical benefits are related primarily to pleiotropic effects of statins (endothelial function, inflammation, coagulation and plaque … canon laser toner cartridge priceWebbMost pleiotropic effects of statins in cell cultures can be reversed by the addition of mevalonate. Effects that are mediated by Rho GTPases are attributed to the isoprenoid, geranylgeranlpyrophosphate (GGPP). Therefore, increasing mevalonate or GGPP concentrations within extra hepatic cells could limit the benefits of statins. flagship travelWebb22 apr. 2024 · More than 35 million Americans take statins, most of whom are prescribed Atorvastatin being one of the most popular prescription drugs of its kind. Here are some of the many benefits of taking Atorvastatin medication for patients:. Taking Atorvastatin benefits the body’s cholesterol levels.; Atorvastatin works primarily by reducing low … flagship travel agency marblehead maWebbBeneficial Cardiovascular Pleiotropic Effects of Statins Jean Davignon, MD Abstract—Pleiotropic effects of a drug are actions other than those for which the agent … flagship twitter